SCHOOL OF NATURAL SCIENCES
Centre for Life Sciences

Profile of Faculty

Rajakishore Mishra, Ph.D.

Assistant Professor
Centre for Life Sciences

Ph.D. (2005)     Institute of Life Sciences, Bhubaneswar (Utkal University, India) Subject: Life Sciences
JRF/NET - C.S.I.R  (1999)     Subject: Life Sciences
M. Sc. Zoology (1997)   Berhampur University; Special Paper: Cell Physiology and Biochemistry
(Career First Class / Distinction all through)


Cell: +91- 9470575594
E-Mail rajakishore.mishra@cuj.ac.in

Employment:

Assistant Professor- Central University of Jharkhand   (May, 2011 onwards  )
Senior Research Associate (CSIR) Utkal University. (March, 2011 to May, 2011)
Guest Faculty- Dept. of Biotechnology, U.U. (August, 2010 to March, 2011)
Postdoctoral Research Associate - Loyola University, Chicago, USA. (Sept, 2007 to May 2010), and Texas A&M University HSC, USA. (May, 2005 to Aug, 2007)

Courses Taught in CUJ:

Ph.D: Research Methodology.

PG: Cancer Biology and Therapeutics; Genomics, Proteomics and Metabolomics; Biomembrane and Bioenergetics; Animal Developmental Biology & Endocrinology.

UG: Biochemistry; Bio-techniques; Cell Biology; Systematics and Biodiversity of Animals; Animal Physiology.  

Scientific Focus:

The goal of my research group is to understand the molecular basis of cancer, with emphasis on basic mechanisms of signal transduction and its effect on human oral tumour progression, invasion and chemo resistance. Little is known about the cause of this neoplasm, despite recent advances in cancer biology. The oral tumour (mainly oral squamous cell carcinoma) is controlled by intracellular cell signaling networks and activation of numerous pathways, promotes transformation of normal oral mucosa to cancerous tumours. Our recent studies have begun addressing how, the normal oral mucosa cells gain the ability to transform towards hyperplasia, dysplasia and eventually metastasize to regional and distant organs or causing drug resistance in by the influence of various signaling pathways.  The therapeutic advantage in animal model by targeting chemically induced tumours with natural compound gives an indication for treating this neoplasm. The long term aim of my group is to identify suitable biomarkers / novel therapeutic targets for effective disease management and to treat oral cancer.

Publications (from CUJ):

Pramanik KK, Singh AK, Alam M, Tanushree, Mishra P, Panda AK, Dey RK, Rana A, Nagini S,  Mishra R*. Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer Tumor Biology 2016 37(11):15253-15264. [Springer Publications; ISSN: 1010-4283]

 

Josephraj S, Tanagala KKK, Jaganathan K, Mishra R, and Nagini S. Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis. Sci. Rep. 2016. 6: 22192. [Nature Publications; ISSN: 2045-2322]

 

Mishra R*, Nagini S, Rana A. Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression. Mol Cancer 2015. 14(1):20. [BioMed Central; ISSN: 1476-4598] 

 

Kavitha K, Thiyagarajan P, Rathna Nandhini J, Mishra R, Nagini S. Chemopreventive effects of diverse dietary phytochemicals against DMBA-induced hamster buccal pouch carcinogenesis via the induction of Nrf2-mediated cytoprotective antioxidant, detoxification, and DNA repair enzymes. Biochimie  2013, 95(8): 1629-39. [Elsevier Science;  ISSN:0300-9084] 

 

Mishra R. Cell cycle-regulatory cyclins and their deregulation in oral cancer. Oral Oncology 2013. 49(6): 475-81. [Elsevier Science;  ISSN: 1368-8375] 

 

Yedida GR, Nagini S, Mishra R*. The importance of oncogenic transcription factors for oral cancer pathogenesis and treatment. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2013. 116 (2):179-88.  [Elsevier Science;  ISSN:1079-2104] 

 

Rana A, Rana B, Mishra R, Sondarva G, Rangasamy V, Das S, Viswakarma N, Kanthasamy A.  Mixed Lineage Kinases (MLKs)-JNK Axis: A potential Therapeutic Target in Cancer. Genes & Cancer 2013. 4(9-10):334-341.[SAGE Publications; ISSN: 1947-6019]  

 

Siddavaram N, Ramamurthy, VP, Veeran V, Mishra R. Chlorophyllin  abrogates canonical Wnt/b catenin signaling pathway and angiogenesis to inhibit the development of DMBA induced hamster cheek pouch carcinoma. Cell Oncol (Dordr) 2012. 35(5): 385-395. [Springer:  ISSN: 2211-3428]

 

Mishra R. Biomarkers of premalignant oral epithelial lesions for clinical application. Oral Oncology 2012. 48: 578-584 [Elsevier Science; ISSN: 1368-8375]

For detail Publications:   http://www.ncbi.nlm.nih.gov/pubmed/?term=rajakishore+mishra

Editorial for Scientific Journals :

JSM Head & Neck Cancer-Cases and Reviews; Publisher: JSciMed Central

Referee for Scientific Journals (Selected):

Oncotarget. (Publisher: Impact Journals, ISSN: 1949-2553)
British Journal of Cancer. (Nature Publishing Group, ISSN: 0007-0920)
Experimental Cell Research. (Elsevier Science, ISSN: 0014-4827)
BMC Cancer. (Biomed Central, ISSN: 1471-2407)
Apoptosis. (Springer, ISSN: 1360-8185)Expert Opinion on Therapeutic Target  (informa health care, ISSN: 1472-8222)
Current Drug Target. (Bentham Science, ISSN: 1389-4501)
Molecular Carcinogenesis (John WILEY & Sons, Inc., ISSN: 1098-2744)
Head and Neck (John WILEY & Sons, Inc., ISSN: 1097-0347)

Professional Membership:

Indian Association for Cancer Research (IACR)
Environmental Mutagenesis, Carcinogenesis and Health (EMCH)
American Association for Cancer Research (AACR)
European Association for Cancer Research (EACR)
The American Society for Cell Biology (ASCB)

Organizational Activity/ Session Chair (International Conferences):

Organizing Secretary: International Symposium on “Advances in Cancer Research: Drug Discovery to Delivery”. This was jointly organized by Central University of Jharkhand (CUJ) and Carcinogenesis Society, USA at CUJ (Nov19. 2013).

Chairperson of a symposium: International Conference, The 34th Convention of IACR (Symposium on Innovations in Cancer Treatment and Research, Jaipur, Rajasthan, India on 21st Feb. 2015.

Chairperson of a Session: International Conference, International Conference on Environmental Mutagenesis, Carcinogenesis and Health and 40th Annual Meeting of EMSI from February 17-19, 2016 (ICEMCH2016) Amritsar, India.        

 

Co-chairperson of a Session: International Conference, Cancer Screening & Diagnosis Radiation, Surgical and Medical oncology and Anti-Cancer Drug Discovery & Therapy at World Congress on Cancer Research & Therapy on Nov 21-23, 2016 at Miami, Florida, USA.

Research Activity in CUJ:

Lab Members
Postdoctoral Research Associate

  1. Dr. Abhay K. Singh, (NET-LS,RA-DBT)
    (Topic of research: p70 S6K signaling and its contribution in human oral cancer)

Research scholars (Enrolled for Ph.D.)

  1. Mr. Kamdeo K. Pramanik (M.Sc, JRF-CSIR)
    (Topic of research: Role and regulation of MMP-2 and -9 in human oral cancer progression) Publication -PMID:27696293
  2. Mr. Manzar Alam (M.Sc, NET-LS)
    (Topic of research: Targeting key regulatory apoptotic molecules / activating pathways in oral squamous cell carcinoma for  enhancing cytotoxic drug induced chemo-sensitization)
  3. Ms Tanushree (M.Sc., JRF-CSIR)
    (Topic of research: Identification of oral cancer  stem cells (CSC) in invasive and chemo-resistant human oral tumour)

Research Technicians

  1. Ms. Sneha Kumari (M.Sc.)    

M. Sc. Dissertation Work (Continuing 2016-17) 3 Students
1. Mr Archisman Banerjee
2. Ms Ruby Gupta
3. Ms Arpita Jha

M. Sc. Dissertation Work (Completed 2015-16 ) 4 Students

M. Sc. Dissertation Work (Completed 2014-15 )  4 Students

Recent Research Presentations (Personally presented):

Awakening GSK3beta (glycogen synthase kinase 3beta), the resting conqueror, to fight against human oral epithelial cancer. World Congress on Cancer Research & Therapy  on Nov 21-23, 2016 at Miami, FL, USA. (Invited Talk)

Aggressiveness of tobacco mediated human oral cancer and the role of glycogen synthase kinase 3 isoforms α/β signaling. International Conference on Environmental Mutagenesis, Carcinogenesis and Health and 40th Annual Meeting of EMSI from February 17-19, 2016 (ICEMCH-2016) Amritsar, India. (Invited Talk)

Role of glycogen synthase kinase-3 in human oral tumour progression. 34th Convention of IACR (Feb 19-21, 2015), Jaipur, India.

Hypermethylation of RECK gene promoter in human oral tumours and its correlation with glycogen synthase kinase -3 inactivation. 2nd International Conference on Frontiers In Biological Sciences (InCoFIBS – 2015) (22 - 24th January, 2015), NIT Rourkela, India (Oral Presentation)

Role and Regulation of Glycogen Synthase Kinase-3 in Oral Cancer. National Conference on Biotechnology (March 29-31, 2014) at PG Dept. of Biotechnology, Utkal University, Bhubaneswar, India. (Invited Talk)

Cyclins as effective biomarkers for targeting oral cancer. International Symposium on “Advances in Cancer Research: Drug Discovery to Delivery” 2013, CUJ, Ranchi, India. Emerging Scientist S14. Vol 2 Supp-1, ISSN : 2166-5060

The importance of efficient early diagnosis and targeted therapy for treating chewing tobacco mediated oral cancer. “National Conference on Recent Advances in Science for Technology -2012, VSSUT, Burla, Odisha, India. (Invited Talk)

Identification of novel therapeutic target for oral squamous cell carcinoma. Tata Memorial Centre, Advance Center for Treatment, Research and Education in Cancer, Navi Mumbai, India. 2012 (Journal of Cancer Research and Therapeutics. 2012. 8: Supp-1: S30)

Research Support:

  1. Project entitled “Evaluation of therapeutic potential of glycogen synthase kinase 3 in chewing tobacco mediated oral cancer”, in collaboration with Prof. S. Nagini, Anamalai University, Tamil Nadu, India. Role: P.I. ; Funded by D.B.T., Govt. of India   (2013-2016)
  2. Proposal entitled “To define the multidrug resistance gene mdr-1in oral cancer” Role: Co-P.I.; (PI: Prof AN Mishra), Funded by D.B.T. BUILDER, Govt. of India (2014-2019)